![]() And truth be told, of course I had to watch "The Protége" given the fact that Maggie Q was starring in it, as she tends to make some pretty decent action movies. And yeah, that was actually a good thing about the movie, because it is a munch-on-the-popcorn-and-enjoy-the-action kind of movie. The storyline is easily followed and doesn't really require all that much in the intellectual department, so you just switch off the old gray and lean back and enjoy the movie. Sure, the storyline and plot may have been predictable and somewhat generic, but who cares? It made for good wholesome entertainment. This was a good old fashioned action crime thriller, for better or worse. And I must say that I am glad that I opted to watch the movie, because I happened to enjoy the movie. Regardless of how it was playing out, then I would watch it, as the movie had a rather nice cast ensemble. So it was with a bit of doubt that I sat down to watch "The Protége". Initially I was thrilled about getting to sit down to watch "The Protége" from writer Richard Wenk and director Martin Campbell, but someone had mentioned that the movie wasn't really all that great. Although he gives the movie some class, you get the feeling he is slumming it after a career boost from movies such as Birdman and Spotlight. Keaton makes the most of the action scenes which is remarkable given his age. Samuel L Jackson can do this in his sleep. The Protégé is a slickly action thriller let down by a poor plot which holds little surprises. Along the way Ann has several showdowns with the enigmatic Rembrandt who is a fixer for a shady billionaire philanthropist who once faked his own death. The finale ends up in Vietnam where Anna's traumatic past is revealed. Soon people she knows have been killed and Anna goes after the baddies for revenge. One day a man called Rembrandt (Michael Keaton) walks into her shop and Anna's world changes. She also uses a vintage bookshop in London as a front. Moody has trained Anna to be a contract killer. Anna (Maggie Q) was taken in by an assassin called Moody (Samuel L Jackson) who found her as a child in Vietnam. The Protégé has plenty of raw action, some of the violence is hard edged. Nowadays Campbell is a veteran relegated to making B movies. ![]() He was then given the task to reboot the James Bond franchise twice. But will audiences agree? We'll soon find out, as the film is available in theaters now.Īfter you check out The Protégé, make sure you haven't missed any other summer flicks with our release guide.Martin Campbell directed the landmark BBC thriller Edge of Darkness in 1985. ![]() Well, it seems like most critics are pretty disappointed with the thriller. I am more than impressed with what I got from this latest entry in contract killer cinema. He also enjoyed the performances of Q, Keaton, and Jackson, as well as the script, and stated: He applauded Campbell’s direction of the action sequences, as well as the overall balance of action, story, and character. Do all baddies have to drive shiny black Range Rovers and wear thick gold necklaces over their turtlenecks?Īaron Neuwirth from We Live Entertainment had a much more positive opinion of The Protégé than these previous critics. Kennedy also criticized the clumsy writing and storyline overall, saying: While he enjoyed Keaton and Jackson’s performances, he thought there was a hollowness to Q’s role. He thought it asked too much from viewers, as it could never quite figure out the kind of movie it wanted to be. Mark Kennedy from Associated Press was also disappointed with the action thriller. It tries so hard to make you think it’s smart that its dumbness is impossible to forgive.
0 Comments
![]() See also: Timeline of the Mahsa Amini protests The government's response to the protests has been widely condemned. In addition to demands for increased rights for women, the protests have demanded the overthrow of the Islamic Republic, setting them apart from previous major protest movements in Iran, which have focused on election results or economic woes. Women, including schoolchildren, have played a key role in the demonstrations. Supreme Leader Ayatollah Ali Khamenei dismissed the widespread unrest not only as "riots" but also as a “hybrid war" caused by foreign states and dissidents abroad. An estimated 19,262 have been arrested throughout at least 134 cities and towns, and at 132 universities. At least 488 people, including 64 minors, had been killed as a result of the government's intervention in the protests, as of 27 January 2023. Īlthough the protests have not been as deadly as those in 2019 (when more than 1,500 were killed), they have been "nationwide, spread across social classes, universities, the streets schools", and called the "biggest challenge" to the government of Iran since the Islamic Revolution in 1979. As the protests spread from Amini's hometown of Saqqez to other cities in the Iranian Kurdistan and throughout Iran, the government responded with widespread Internet blackouts, nationwide restrictions on social media usage, tear gas and gunfire. According to eyewitnesses, she had been severely beaten by Guidance Patrol officers, an assertion denied by Iranian authorities. Amini had been arrested by the Guidance Patrol for allegedly violating Iran's mandatory hijab law by wearing her hijab "improperly" while visiting Tehran from Saqqez. Ĭivil unrest and protests against the government of Iran associated with the death in police custody of Mahsa Amini ( Persian: مهسا امینی) began on 16 September 2022 and are ongoing as of May 2023. ![]() Īs of 4 November 2022, over 14,000 were arrested throughout 134 cities and towns, and at 132 universities (HRANA). More than 300 protesters killed, including more than 30 minors, in 25 out of 31 provinces ( United Nations), as of 22 November 2022 Ģ00 killed (state media) as of 3 December 2022 Ĩ98+ as of 26 September 2022 Īs many as 19,262 ( HRANA, as of 6 January 2023). At least 488 protesters including 64 minors killed ( Iran Human Rights) as of 27 January 2023 ĥ17 protesters including 70 minors killed, as well as 68 security force members ( HRANA), as of 6 January 2023 You can start the execution of all the tasks included in a profile by using these.Īn exit button. ![]() The Task List which lists all the available tasks of the current profile.ģ buttons that refer to specific task handling (add – remove – modify).Ī start button and a simulation check-box. Once it opens you should see similar to the following screen It consists of :Ī toolbar that refers to current profile handling. A new sync folder can be added by clicking on the plus button above the paths of used sync folders. You can open luckybackup from Applications->Accessories->luckyBackup Synkron supports synchronising multiple folders at the same time. A change detection job enumerates every file in the file share, and then compares it to the sync version for that file. Install luckybackup using the following command Update the source list using the following command ![]() will make sure those changes get carried over to the synchronized folder. Gpg -export 62E44DBB -a | sudo apt-key add - Compared to File-based increments applications, these are more space-efficient, especially when large files receive small modifications on the other hand, the. The program can also synchronize your files automatically when it detects that. Or click on the following link from firefox If we made changes in different locations in this document, after re-connecting network, we will found the changes we made will be also synced to this document stored in Teams at the same time without any notification. It is simple to use, fast (transfers over only changes made and not all data), safe (keeps your data safe by checking all declared directories before proceeding in any data manipulation ), reliable and fully customizable. ![]() Its main features are: backup, safety, synchronization, exclude/only include options, allows custom rsync options, remote connections, restore and dry-run operations, scheduling, profiles and command line mode. LuckyBackup is an application that backs-up and/or synchronizes any directories with the power of rsync. ![]() Death Wish Coffee is typically sourced from India and Peru, but they are constantly sampling and testing Organic and Fair Trade coffee beans from all over the world to ensure customers get the strongest coffee on Earth. So, how do they do it? It starts with the bean blend. But don’t just take their word for it.Īccording to Consumer Reports, an 8oz cup of Death Wish Coffee contains around 472 mg of caffeine compared to an 8 oz cup of Starbucks’ dark roast that contains 260 mg of caffeine or your normal house coffee that contains around 120 mg of caffeine. How much caffeine is in Death Wish Coffee?ĭeath Wish Coffee says that their unique roast is “…two times more caffeinated than your average coffee house cuppa joe” per 6 oz cup. Expensive compared to grocery store coffee. ![]() Only comes in dark roast Now have medium roast!.Comes in whole bean, ground, pods, pour-over, instant, and cold-brew.Strong and smooth, not bitter, with high caffeine content.They do this by carefully selecting the highest quality Organic and Fair Trade coffee beans and then perfectly roasting them to produce a bold, yet smooth, highly caffeinated coffee blend. All opinions are our own.īy Alison Chew | Dietitian Verified by Rebecca Housh, MS, RDNĭeath Wish Coffee brings you the STRONGEST COFFEE IN THE WORLD. This Death Wish Coffee review contains affiliate links and we may be compensated if you make a purchase. ![]() We finished our meals and opted against desert due to how full we both were, although I expect their desserts to be just as good as the service and food we had received on that evening. The Pizzaâs presentation was superb as they came out, my partner chose the tomato, mushroom, bacon, onion, and blue cheese pizza whilst I went for the rocket, Parma harm and feta cheese pizza which was very light and went down a treat! I tried my partners pizza and itâs fair to say, if youâre a lover of blue cheese, her pizza would be the one for you as it almost blew my socks off! Iâm not an avid lover of strong cheese but the cheese for me overwhelmed the taste of the other ingredients, this isnât a negative in terms of the pizza, just my partners and I personal preference. Pizza in Italy is a must beyond all accounts, and the Pizzaâs here were delicious! For starters, my partner and I shared the Fruit Salad, consisting of freshly cut melon, apple, pear, and mango â accompanied with quinoa and fresh Parma harm. Adjustments to recipes cannot be made during class.This was another recommendation on behalf of our AirBnB host and yet again, this place did not disappoint! We were fortunate enough to sit outside towards the back of the restaurant whereâs itâs lit up with fairy lights to add to the tranquil atmosphere. If you have a food allergy, please check with me sending an email at before attending the class. To book write me back at a Spillo recipes are developed using common cooking and baking ingredients that may or may not be specified in the menu titles, including various fruits and vegetables, nuts, meats, spices, wheat flours, etc. The cost is 60 euros for 3-hour class (Wine tasting is included of course!). I also believe that food & drinks are the best way to SEW TIGHT TIES.and this is what we’ll do during these classes! Quando ci sar la prossima ondata di caldo venite da noi: i nostri spazi climatizzati garantiscono un'aria ben. Sapremo stupirvi con le nostre ricette prelibate in un ambiente davvero unico. Who will enjoy only 1 class will receive the recipes at the end of the lesson.Ĭlasses are planned once in a week, 4 times each month. Restaurant Pizzeria Spillo Treviso - Una serata tra amici con delizioso cibo italiano: abbiamo per voi piatti freschi, preparate al momento, in un'atmosfera genuina. Students who will enjoy the entire course of 4 classes will receive an apron besides all the recipes.«Vista questa unione con la pastorale del MMFI abbiamo pensato di arricchire la nostra spiritualità col. La comunità si adesso anche delle Reliquie di Primo Grado del Beato Carlo Acutis. You will enjoy a generous taste of every dish and will drink very good Italian wine. A Rapone ormai sono già alcuni anni che la Parrocchia San Nicola Vescovo è custode delle Reliquie dei santi Francesco e Giacinta Pastorelli di Fatima.Please wear comfortable and have long hair tied back.You will be standing, cooking and working for most of the class.Hands-on classes are limited to min.2 max.6 students. ![]() You will work with other students in groups of 2.In my classes you’ll work together with other students (max 6-7 so you all can practice) in a fun, hands-on environment led by a passionate food entertainer (me!) nb: ALL LESSONS ARE ENGLISH SPEAKING! Great Italian cooking is especially about authentic recipes! And this is what you’ll know joying this class! I mean… original carbonara, pasta alla bolognese or crispy fiori di zucca with real mozzarella di bufala heart!ĭuring this hands-on class, you’ll hone basic Italian cooking skills and practice the fundamental recipes, plus, I will teach you a few tricks about the best products to buy and offer tips for cooking at the best and simplest way! …by learning how to cook typical italian dishes, of course! □ 3 reviews of Quattro Archi di Grasso Rosario 'Excellent food, service and atmosphere We absolutely recommend this little gem. What’s the best way to approach the Italian culture? If you are an M-1 student, your prospective employer may petition H-1B status on your behalf if your employment does not relate to your M-1 program of study. ![]() An F-1 student’s current or prospective employer may petition USCIS for H-1B status on their behalf by filing Form I-129, “Petition for a Nonimmigrant Worker.” International Students and H-1B StatusĮach year, some F-1 students seek to switch nonimmigrant classification from F-1 student status to H-1B temporary employment status after completing a program of study or post-completion optional practical training (OPT). This means that once USCIS reaches the cap in one fiscal year, employers must wait until April 1, which is six months before the start of the next fiscal year, before filing H-1B petitions again. Regulations prohibit employers from filing H-1B petitions until six months before the date of actual need for the employee. For more information on the H-1B cap, visit USCIS’s H-1B Fiscal Year (FY) 2018 Cap Season page. For purposes of the cap, each fiscal year begins on Oct. There is a limit, or “cap,” on the number of individuals who can receive H-1B status every fiscal year. An employer may petition United States Citizenship and Immigration Services (USCIS) for H-1B status on behalf of an employee/prospective employee if the candidate holds “theoretical or technical expertise in specialized fields." USCIS is the government agency responsible for adjudicating H-1B petitions and granting H-1B status. Thank you in advance.The H-1B status is temporary employment authorization for a nonimmigrant who performs services in a specialty occupation. My case and description may be wordy, but I do need your help and advice. My question is how can I maximize my benefits in the transition period (assuming I will receive the official H1B VISA by Oct 1st). I hope I could register as fewer credits as possible but legally work for my sponsor to compensate for the living expense. There is no confliction between H1B VISA and part-time student (It could be either self-supported or company sponsorship.). I do investigate the possibility of doing a part-time Ph.D. Can I register 2 or 3 credits CPT course in this upcoming fall as a part-time student and work for my sponsor again while maintaining my legal immigration status? In this summer semester, I registered 2 credits of CPT so that I could work for my sponsor in the summer. Here come to my questions:ĭo I have to register the course as usual to maintain my F1 status to stay in the US? (Since my VISA status is changing, I don’t know if I got some special period that I can legally stay in the US without registering as a full-time student.) To maintain my F1 status before I get the work VISA, I must register 9 credits hours as a full-time student in fall. Now I’m waiting for the official documents.Īs you all know, it is almost the fall semester when the regular international student must register the courses. Please follow the instructions in the notice). My sponsor submitted the H1B petition in April and finally, I luckily got picked in the pool and the petition got approved (Case status: On May 23, 2019, we approved your Form I-129, Petition for a Nonimmigrant Worker. However, I found a company that willing to sponsor me a work VISA. program in April (actually, my adviser stop my funding to force me to leave the US.). Due to the bad relationship with my advisor, I quit from the current Ph.D. ![]() Based on the approved WaveLab Pro mastering solution, the WaveLab Elements highlights proven editing and analysis tools, a valuable selection of restoration and mastering plug-ins, a CD burning engine and much more - all accessible through an intuitive user interface. WaveLab Elements automatically creates crossfades, letting you arrange, cut, fade, and blend music and voices exactly to your taste. ![]() Bit Rate / Bit Depth / Sample Rate WAV Bit Depth. For the high-volume audio shop, this sort of thing could cost-justify the. Get stuck when faced with all of these options like WAV MP3 FL Studio Export Options. ![]() WaveLab Elements 9 WaveLab Elements is an audio editing and mastering software, perfectly tailored to hobby musicians, radio freelancers and home studio owners. A watch folder can be created to automatically invoke an mp3 copy operation. You should notice some speed gain when you reboot your Mac machine. Select those you don’t want and hit the Remove button. You’ll see a list of small helper and service applications that automatically run after your Mac boots up.Click on Optimization > View All Items > Launch Agents.Select these apps that you don’t need to auto startup and hit the minus “ –” option.Click on System Preferences (System Settings on macOS Ventura and above) > Users & Groups > Login Items.Click on the Apple menu from the top left corner.The fewer programs that run automatically on startup, the faster your Mac will be. Take a look at what startup apps or auto launch agents you have running and stop as many of these from opening as possible. ![]() Disable Startup Items (Apps & Hidden Launch Agents)īest for: When your Mac is slow to start up. If you find that your Mac is too old to run macOS Monterey, it’s probably a good idea to revert to an older version since you’ll encounter more performance issues after updating and there aren’t many tricks you can play around with to speed up your machine. Also, the installer file of macOS Monterey is 12GB, but you’ll need at least 35GB of free storage on your Mac for the new system to run, preferably 50GB or even more. If your Mac machine is showing its age, it’s going to have a difficult time running the latest operating system, or even not compatible with the latest version at all.Ĭlick here to learn the list of macOS Monterey supported Macs and check whether your Mac is on the list or not. Every new macOS that Apple has released has a minimum requirement on hardware. Technically speaking, this is not a fix but it’s worth checking as the first step. Check Whether Your Mac is Compatible with Monterey If one particular fix doesn’t work, try another one. Note: there are many possible reasons behind a slow Mac, we’ll start with the basic fixes. We are going to share with you some of the best tips and tricks. If you are facing one of those macOS Monterey slow issues with your Mac (iMac, MacBook Pro, MacBook Air), read on to find out how to fix it. ![]() Internet becomes super slow and it’s impossible to watch YouTube videos.The fan is constantly running and has high noise.Apps are slow to open or keeps freezing.We are all excited about the new macOS and hit the update button, only to find our Mac experiencing performance issues such as the machine runs slow after updating to macOS Monterey. Upgraded FaceTime, Universal Control across devices with single mouse or trackpad, improved Safari browsing experience, privacy enhancements, the list go on. As an Amazon Associate, We earn a commission from qualifying purchases at no extra cost to you.Īlthough the new macOS 12 Monterey is a smaller update compared to Big Sur, it’s still packed with lots of amazing features. Your Friends At Jack Daniel’s Remind You To Drink Responsibly. A simple reminder that quality and responsibility never go out of style. Discover our story of independence, our family of whiskeys, recipes, and our distillery in Lynchburg, Tennessee. Tennessee Whiskey the Musical is a new Broadway-style musical about the rise of songwriting icon DEAN DILLON, his personal struggles with alcoholism and. This commitment to quality, along with the unique charcoal-mellowed flavor, has led to Jack Daniel’s fame around the world. Welcome to Jack Daniel's Tennessee Whiskey. The folks there still use the same care and methods that Jack Daniel established back in 1866. Just like Jack Daniel’s Whiskey, our coffee blend is crafted with pride using premium beans and proprietary roasting methods for a delicious brew with bold character and a smooth finish.Įvery drop of Jack Daniel’s Tennessee Whiskey is made in Lynchburg, Tennessee at America’s oldest registered distillery. (a) An intoxicating liquor may not be advertised, described, labeled, named, sold or referred to for marketing or sales purposes as Tennessee Whiskey. Jack Daniel, “Everyday we make it, we’ll make it the best that we can.” We have been roast masters since 1984 and adhere to strict quality standards in the sourcing and production of the best tasting coffee. World of Coffee operates using the same principles as Mr. Roaming Man Tennessee Straight Rye Whiskey boasts a bold expression of black pepper, vanilla, caramel, tobacco and oak. 7 Tennessee Whiskey are evident in each sip. The distinct caramel and vanilla notes of Jack Daniel’s® Old No. ![]() Our unique blend of gourmet coffee is 100% Arabica, infused with authentic Jack Daniel’s® Tennessee Whiskey, and roasted medium to provide a full-bodied rich flavor. Evidence for distinct mechanisms facilitating transcript elongation through chromatin in vivo. Splitting of H3–H4 tetramers at transcriptionally active genes undergoing dynamic histone exchange. The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Genome-scale profiling of histone H3.3 replacement patterns. Nucleosome displacement in transcription. Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription. Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes. Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. By suppressing spurious cryptic transcripts from initiating within ORFs, this pathway is essential to maintain the accuracy of transcription by RNA polymerase II.Ĭarrozza, M. Thus, Set2 functions both to suppress the incorporation of acetylated histones and to signal for the deacetylation of these histones in transcribed genes. In addition to its function of targeting and activating the Rpd3S complex, H3K36 methylation suppresses the interaction of H3 with histone chaperones, histone exchange over coding regions and the incorporation of new acetylated histones. Here we show that, in yeast, co-transcriptional acetylation is achieved in part by histone exchange over ORFs. Although the co-transcriptional deacetylation pathway is well characterized, the factors responsible for acetylation are as yet unknown. In the absence of Set2, H3K36 or Rpd3S acetylated histones accumulate on open reading frames (ORFs), leading to transcription initiation from cryptic promoters within ORFs 1, 3. J Clin Oncol 2017 35:1061–9.Set2-mediated methylation of histone H3 at Lys 36 (H3K36me) is a co-transcriptional event that is necessary for the activation of the Rpd3S histone deacetylase complex, thereby maintaining the coding region of genes in a hypoacetylated state 1, 2. Ki67 proliferation index as a tool for chemotherapy decisions during and after neoadjuvant aromatase inhibitor treatment of breast cancer: results from the American College of Surgeons Oncology Group Z1031 trial (Alliance). J Clin Oncol 2011 29:2342–9.Įllis MJ, Suman VJ, Hoog J, Goncalves R, Sanati S, Creighton CJ, et al. Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype–ACOSOG Z1031. Cancers 2021 13:2538.Įllis MJ, Suman VJ, Hoog J, Lin L, Snider J, Prat A, et al. The present and future of neoadjuvant endocrine therapy for breast cancer treatment. Neoadjuvant endocrine therapy in breast cancer management: state of the art. ![]() Neoadjuvant endocrine therapy in locally advanced estrogen or progesterone receptor-positive breast cancer: determining the optimal endocrine agent and treatment duration in postmenopausal women-a literature review and proposed guidelines. ©2022 The Authors Published by the American Association for Cancer Research. ![]() The ypStage 0/I rate and PEPI = 0 rate were similar with respect to SET2,3. This exploratory analysis of Z1031 data demonstrated a higher rate of pharmacodynamic suppression of proliferation and longer EFS in high SET2,3 disease relative to low SET2,3 disease. Patients with high SET2,3 had longer EFS than patients with low SET2,3 (HR, 0.52, 95% confidence interval: 0.34-0.80 P = 0.0026). Patients with high SET2,3 had higher rate of pharmacodynamic response than patients with low SET2,3 (Ki67 ≤ 10% in 88.2% vs. Cox models were used to assess EFS with respect to SET2,3 excluding cohort B patients who switched to chemotherapy. Fisher exact test was used to assess the association between SET2,3 and low proliferation at week 2-4 and PEPI-0 rate in cohort B, and the association between SET2,3 and ypStage 0/I in all patients. To evaluate prediction of response and event-free survival (EFS) following neoadjuvant endocrine therapy by SET2,3 index of nonproliferation gene expression related to estrogen and progesterone receptors adjusted for baseline prognosis.Ī correlative study was conducted of SET2,3 measured from gene expression profiles of diagnostic tumor (Agilent microarrays) in 379 women with cStage II-III breast cancer from the American College of Surgeons Oncology Group Z1031 neoadjuvant aromatase inhibitor trial SET2,3 was dichotomized using the previously published cutoff. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |